Involvement of NF-κBIL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Joint Authors
Waldum, Helge L.
Li, Zhenfeng
Cui, Guanglin
Cui, Jing
Ren, Jingli
Yang, Hang
Qi, Haili
Source
International Journal of Inflammation
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC).
In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model.
Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues.
The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points.
The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times.
These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes.
American Psychological Association (APA)
Yang, Hang& Qi, Haili& Ren, Jingli& Cui, Jing& Li, Zhenfeng& Waldum, Helge L.…[et al.]. 2014. Involvement of NF-κBIL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice. International Journal of Inflammation،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448147
Modern Language Association (MLA)
Yang, Hang…[et al.]. Involvement of NF-κBIL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice. International Journal of Inflammation No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-448147
American Medical Association (AMA)
Yang, Hang& Qi, Haili& Ren, Jingli& Cui, Jing& Li, Zhenfeng& Waldum, Helge L.…[et al.]. Involvement of NF-κBIL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice. International Journal of Inflammation. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-448147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448147