Drug Resistance and the Role of Combination Chemotherapy in Improving Patient Outcomes
Author
Source
International Journal of Breast Cancer
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Resistance to cancer chemotherapy is a common phenomenon especially in metastatic breast cancer (MBC), a setting in which patients typically have had exposure to multiple lines of prior therapy.
The subsequent development of drug resistance can result in rapid disease progression during or shortly after completion of treatment.
Moreover, cross-class multidrug resistance limits patient treatment choices, particularly in a setting where treatments options are few.
One attempt to minimize the impact of drug resistance has been the concurrent use of two or more chemotherapy agents with unrelated mechanisms of action and differing modes of drug resistance, with the intent of blocking the development of multiple intracellular escape pathways essential for tumor survival.
Within the past decade, an array of mechanistically diverse agents has augmented the list of combination regimens that may be both synergistic and efficacious in pretreated MBC.
The aim of this paper is to review mechanisms of resistance to common chemotherapy agents and to consider current combination treatment options for heavily pretreated and/or drug-resistant patients with MBC.
American Psychological Association (APA)
Yardley, Denise A.. 2013. Drug Resistance and the Role of Combination Chemotherapy in Improving Patient Outcomes. International Journal of Breast Cancer،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-448657
Modern Language Association (MLA)
Yardley, Denise A.. Drug Resistance and the Role of Combination Chemotherapy in Improving Patient Outcomes. International Journal of Breast Cancer No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-448657
American Medical Association (AMA)
Yardley, Denise A.. Drug Resistance and the Role of Combination Chemotherapy in Improving Patient Outcomes. International Journal of Breast Cancer. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-448657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-448657