Alleviation of Plasma Homocysteine Level by Phytoestrogen α-Zearalanol Might Be Related to the Reduction of Cystathionine β-Synthase Nitration
Joint Authors
Liu, Teng
Wang, Wen
Lu, Lingqiao
Ma, Lu
Zhen, Panpan
Song, Dandan
Liu, Xin
Zhang, Hui
Sun, Qi
Zuo, Xiaoyun
Zhang, Xin
Wang, Ke
Liu, Huirong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-24
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hyperhomocysteinemia is strongly associated with cardiovascular diseases.
Previous studies have shown that phytoestrogen α-zearalanol can protect cardiovascular system from hyperhomocysteinemia and ameliorate the level of plasma total homocysteine; however, the underlying mechanisms remain to be clarified.
The aim of this research is to investigate the possible molecular mechanisms involved in ameliorating the level of plasma homocysteine by α-zearalanol.
By the successfully established diet-induced hyperhomocysteinemia rat models, we found that, after α-zearalanol treatment, the activity of cystathionine β-synthase, the key enzyme in homocysteine metabolism, was significantly elevated and level of nitrative stress in liver was significantly reduced.
In correlation with this, results also showed a decreased nitration level of cystathionine β-synthase in liver.
Together data implied that alleviation of plasma homocysteine level by phytoestrogen α-zearalanol might be related to the reduction of cystathionine β-synthase nitration.
American Psychological Association (APA)
Liu, Xin& Zhang, Xin& Song, Dandan& Zuo, Xiaoyun& Liu, Huirong& Wang, Wen…[et al.]. 2014. Alleviation of Plasma Homocysteine Level by Phytoestrogen α-Zearalanol Might Be Related to the Reduction of Cystathionine β-Synthase Nitration. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-449187
Modern Language Association (MLA)
Liu, Xin…[et al.]. Alleviation of Plasma Homocysteine Level by Phytoestrogen α-Zearalanol Might Be Related to the Reduction of Cystathionine β-Synthase Nitration. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-449187
American Medical Association (AMA)
Liu, Xin& Zhang, Xin& Song, Dandan& Zuo, Xiaoyun& Liu, Huirong& Wang, Wen…[et al.]. Alleviation of Plasma Homocysteine Level by Phytoestrogen α-Zearalanol Might Be Related to the Reduction of Cystathionine β-Synthase Nitration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-449187
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449187