Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus
Joint Authors
Kobayashi, Junji
Ito, Naoko
Liu, Jianhui
Okamoto, Takuya
Nohara, Atsushi
Ohbatake, Azusa
Yamagishi, Masakazu
Yagi, Kunimasa
Okazaki, Satoko
Mori, Yukiko
Takeda, Yoshiyu
Nakano, Kaoru
Asano, Akimichi
Yamaaki, Naoto
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Although retinol-binding protein 4 (RBP4) associates with insulin resistance and remnant-like particles triglyceride (RLP-TG) elevated in the insulin resistant state, few data exist regarding the relationship between RBP4 and RLP-TG.
Subjects and Methods.
The study included 92 Japanese type 2 diabetic mellitus (T2DM) male patients (age 60.5±13.6 years, body mass index (BMI) 24.7±4.1 kg/m2, waist circumference (WC) 88.4±10.7 cm, and HbA1c (NGSP) 7.2±1.9%).
Patients on medications affecting insulin sensitivity, including fibrates, biguanides, and thiazolidinedione, were excluded.
Visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by computed tomography.
Results.
RBP4 levels showed a significant positive correlation with RLP-TG (r=0.2544 and P=0.0056), TG (r=0.1852 and P=0.041), RLP-TG/TG (r=0.23765 and P=0.0241), and age (r=−0.2082 and P=0.0219), although there was no significant correlation with VFA, SFA, adiponectin levels, or homeostasis model of assessment insulin resistance (HOMA-R).
Multiple regression analysis revealed that RBP4 was an independent determinant of RLP-TG (P=0.0193) but was not a determinant of TG.
Conclusions.
RBP4 correlates positively with serum RLP-TG independent of fat accumulation in T2DM.
RBP4 may regulate remnant metabolism independent of glycemic control in T2DM.
American Psychological Association (APA)
Yamaaki, Naoto& Yagi, Kunimasa& Kobayashi, Junji& Nohara, Atsushi& Ito, Naoko& Asano, Akimichi…[et al.]. 2013. Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus. Journal of Diabetes Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-449210
Modern Language Association (MLA)
Yamaaki, Naoto…[et al.]. Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus. Journal of Diabetes Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-449210
American Medical Association (AMA)
Yamaaki, Naoto& Yagi, Kunimasa& Kobayashi, Junji& Nohara, Atsushi& Ito, Naoko& Asano, Akimichi…[et al.]. Impact of Serum Retinol-Binding Protein 4 Levels on Regulation of Remnant-Like Particles Triglyceride in Type 2 Diabetes Mellitus. Journal of Diabetes Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-449210
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449210