Neuroinflammation and Copper in Alzheimer’s Disease
Joint Authors
White, Anthony R.
Alukaidey, Lobna
Grubman, Alexandra
Choo, Xin Yi
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Inflammation is the innate immune response to infection or tissue damage.
Initiation of proinflammatory cascades in the central nervous system (CNS) occurs through recognition of danger associated molecular patterns by cognate immune receptors expressed on inflammatory cells and leads to rapid responses to remove the danger stimulus.
The presence of activated microglia and astrocytes in the vicinity of amyloid plaques in the brains of Alzheimer’s disease (AD) patients and mouse models implicates inflammation as a contributor to AD pathogenesis.
Activated microglia play a critical role in amyloid clearance, but chronic deregulation of CNS inflammatory pathways results in secretion of neurotoxic mediators that ultimately contribute to neurodegeneration in AD.
Copper (Cu) homeostasis is profoundly affected in AD, and accumulated extracellular Cu drives Aβ aggregation, while intracellular Cu deficiency limits bioavailable Cu required for CNS functions.
This review presents an overview of inflammatory events that occur in AD in response to Aβ and highlights recent advances on the role of Cu in modulation of beneficial and detrimental inflammatory responses in AD.
American Psychological Association (APA)
Choo, Xin Yi& Alukaidey, Lobna& White, Anthony R.& Grubman, Alexandra. 2013. Neuroinflammation and Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449303
Modern Language Association (MLA)
Choo, Xin Yi…[et al.]. Neuroinflammation and Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-449303
American Medical Association (AMA)
Choo, Xin Yi& Alukaidey, Lobna& White, Anthony R.& Grubman, Alexandra. Neuroinflammation and Copper in Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-449303
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449303