GluN3A : An NMDA Receptor Subunit with Exquisite Properties and Functions

Abstract EN

N-methyl-D-aspartate receptors (NMDAR) are pivotal for synaptic plasticity and memory formation.

Conventional NMDAR consist of heterotetrameric structures composed of GluN1 and GluN2 subunits.

A third subunit, GluN3, can also assemble with NMDAR subunits giving a remarkable modification of their heteromeric structure, forming a “nonconventional” NMDAR.

As a consequence, the stoichiometry and kinetic properties of the receptors are dramatically changed.

Among the GluN3 family, the GluN3A subunit has been the focus of a large amount of studies during recent years.

These studies reveal that GluN3A is transiently expressed during development and could play a role in the fine tuning of neuronal networks as well as associated diseases.

Moreover, GluN3A distribution outside the postsynaptic densities, including perisynaptic astrocytes, places it at a strategic position to play an important role in the interactions between neurons and glial cells.

This review highlights GluN3A properties and addresses its role in neurophysiology and associated pathologies.