The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias
Joint Authors
Pession, Andrea
Biagi, Carlotta
Serravalle, Salvatore
Masetti, Riccardo
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Acute leukemia is the most common type of childhood and adolescence cancer, characterized by clonal proliferation of variably differentiated myeloid or lymphoid precursors.
Recent insights into the molecular pathogenesis of leukemia have shown that epigenetic modifications, such as deacetylation of histones and DNA methylation, play crucial roles in leukemogenesis, by transcriptional silencing of critical genes.
Histone deacetylases (HDACs) are potential targets in the treatment of leukaemia, and, as a consequence, inhibitors of HDACs (HDIs) are being studied for therapeutic purposes.
HDIs promote or enhance several different anticancer mechanisms, such as apoptosis, cell cycle arrest, and cellular differentiation and, therefore, are in evidence as promising treatment for children and adolescents with acute leukemia, in monotherapy or in association with other anticancer drugs.
Here we review the main preclinical and clinical studies regarding the use of HDIs in treating childhood and adolescence leukemia.
American Psychological Association (APA)
Masetti, Riccardo& Serravalle, Salvatore& Biagi, Carlotta& Pession, Andrea. 2011. The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449566
Modern Language Association (MLA)
Masetti, Riccardo…[et al.]. The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-449566
American Medical Association (AMA)
Masetti, Riccardo& Serravalle, Salvatore& Biagi, Carlotta& Pession, Andrea. The Role of HDACs Inhibitors in Childhood and Adolescence Acute Leukemias. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-449566
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449566