Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement
Joint Authors
Borris, Lars Carl
Lassen, Michael R.
Breindahl, Morten
Pap, Ákos F.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Prothrombin fragment 1+2 is excreted in urine (uF1+2) as a result of in vivo thrombin generation and can be a marker of coagulation status after an operative procedure.
This study compared uF1+2 levels in patients with symptomatic and non-symptomatic venous thromboembolism (VTE) after total knee replacement (TKR) and in event-free sex- and age-matched controls.
Significantly higher median uF1+2 levels were seen in the VTE patients on days 1, 3, and the day of venography (mostly day 7) after TKR compared with controls.
The uF1+2 levels tended to be high in some patients with symptomatic VTE; however, the discriminatory efficacy of the test could not be evaluated.
In conclusion, this study showed that patients with VTE tend to have significantly higher uF1+2 levels compared with patients without events between days 1 and 7 after TKR surgery.
Measurement of uF1+2 could provide a simple, non-invasive clinical test to identify patients at risk of VTE.
American Psychological Association (APA)
Borris, Lars Carl& Breindahl, Morten& Lassen, Michael R.& Pap, Ákos F.. 2011. Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement. Thrombosis،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-449819
Modern Language Association (MLA)
Borris, Lars Carl…[et al.]. Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement. Thrombosis No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-449819
American Medical Association (AMA)
Borris, Lars Carl& Breindahl, Morten& Lassen, Michael R.& Pap, Ákos F.. Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement. Thrombosis. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-449819
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449819