Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer
Joint Authors
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells.
AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary transcript into the mature mRNA.
The combinatorial nature of AS allows a great expansion of the genome coding potential, as multiple splice-variants encoding for different proteins may arise from a single gene.
Splicing is mediated by a large macromolecular complex, the spliceosome, whose activity needs a fine regulation exerted by cis-acting RNA sequence elements and trans-acting RNA binding proteins (RBP).
The activity of both core spliceosomal components and accessory splicing factors is modulated by their reversible phosphorylation.
The kinases and phosphatases involved in these posttranslational modifications significantly contribute to AS regulation and to its integration in the complex regulative network that controls gene expression in eukaryotic cells.
Herein, we will review the major canonical and noncanonical splicing factor kinases and phosphatases, focusing on those whose activity has been implicated in the aberrant splicing events that characterize neoplastic transformation.
American Psychological Association (APA)
Naro, Chiara& Sette, Claudio. 2013. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-449913
Modern Language Association (MLA)
Naro, Chiara& Sette, Claudio. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-449913
American Medical Association (AMA)
Naro, Chiara& Sette, Claudio. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-449913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-449913