Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer

Joint Authors

Naro, Chiara
Sette, Claudio

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-08-28

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Biology

Abstract EN

Alternative splicing (AS) is one of the key processes involved in the regulation of gene expression in eukaryotic cells.

AS catalyzes the removal of intronic sequences and the joining of selected exons, thus ensuring the correct processing of the primary transcript into the mature mRNA.

The combinatorial nature of AS allows a great expansion of the genome coding potential, as multiple splice-variants encoding for different proteins may arise from a single gene.

Splicing is mediated by a large macromolecular complex, the spliceosome, whose activity needs a fine regulation exerted by cis-acting RNA sequence elements and trans-acting RNA binding proteins (RBP).

The activity of both core spliceosomal components and accessory splicing factors is modulated by their reversible phosphorylation.

The kinases and phosphatases involved in these posttranslational modifications significantly contribute to AS regulation and to its integration in the complex regulative network that controls gene expression in eukaryotic cells.

Herein, we will review the major canonical and noncanonical splicing factor kinases and phosphatases, focusing on those whose activity has been implicated in the aberrant splicing events that characterize neoplastic transformation.

American Psychological Association (APA)

Naro, Chiara& Sette, Claudio. 2013. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-449913

Modern Language Association (MLA)

Naro, Chiara& Sette, Claudio. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-449913

American Medical Association (AMA)

Naro, Chiara& Sette, Claudio. Phosphorylation-Mediated Regulation of Alternative Splicing in Cancer. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-449913

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-449913