CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients
Joint Authors
Amato, Aldo
D'Angelo, Rosalia
Rinaldi, Carmela
Crisafulli, Concetta
Ruggeri, Alessia
Sidoti, Antonina
Source
Multiple Sclerosis International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Multiple sclerosis (MS) disease is carried through inflammatory and degenerative stages.
Based on clinical feaures, it can be subdivided into three groups: relapsing-remitting MS, secondary progressive MS, and primary progressive MS.
Multiple sclerosis has a multifactorial etiology with an interplay of genetic predisposition, environmental factors, and autoimmune inflammatory mechanism in which play a key role CC-chemokines and its receptors.
In this paper, we studied the frequency of CCR5 gene Δ32 allele in a cohort of Sicilian RR-MS patients comparing with general Sicilian population.
Also, we evaluate the association between this commonly polymorphism and disability development and age of disease onset in the same cohort.
Our results show that presence of CCR5Δ32 is significantly associated with expanded disability status scale score (EDSS) but not with age of disease onset.
American Psychological Association (APA)
D'Angelo, Rosalia& Crisafulli, Concetta& Rinaldi, Carmela& Ruggeri, Alessia& Amato, Aldo& Sidoti, Antonina. 2011. CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients. Multiple Sclerosis International،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-450048
Modern Language Association (MLA)
D'Angelo, Rosalia…[et al.]. CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients. Multiple Sclerosis International No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-450048
American Medical Association (AMA)
D'Angelo, Rosalia& Crisafulli, Concetta& Rinaldi, Carmela& Ruggeri, Alessia& Amato, Aldo& Sidoti, Antonina. CCR5Δ32 Polymorphism Associated with a Slower Rate Disease Progression in a Cohort of RR-MS Sicilian Patients. Multiple Sclerosis International. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-450048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450048