RNA Splicing : A New Player in the DNA Damage Response

Joint Authors

Lenzken, Silvia C.
Barabino, Silvia M. L.
Loffreda, Alessia

Source

International Journal of Cell Biology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-09-12

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

It is widely accepted that tumorigenesis is a multistep process characterized by the sequential accumulation of genetic alterations.

However, the molecular basis of genomic instability in cancer is still partially understood.

The observation that hereditary cancers are often characterized by mutations in DNA repair and checkpoint genes suggests that accumulation of DNA damage is a major contributor to the oncogenic transformation.

It is therefore of great interest to identify all the cellular pathways that contribute to the response to DNA damage.

Recently, RNA processing has emerged as a novel pathway that may contribute to the maintenance of genome stability.

In this review, we illustrate several different mechanisms through which pre-mRNA splicing and genomic stability can influence each other.

We specifically focus on the role of splicing factors in the DNA damage response and describe how, in turn, activation of the DDR can influence the activity of splicing factors.

American Psychological Association (APA)

Lenzken, Silvia C.& Loffreda, Alessia& Barabino, Silvia M. L.. 2013. RNA Splicing : A New Player in the DNA Damage Response. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-450067

Modern Language Association (MLA)

Lenzken, Silvia C.…[et al.]. RNA Splicing : A New Player in the DNA Damage Response. International Journal of Cell Biology No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-450067

American Medical Association (AMA)

Lenzken, Silvia C.& Loffreda, Alessia& Barabino, Silvia M. L.. RNA Splicing : A New Player in the DNA Damage Response. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-450067

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-450067