α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations
Joint Authors
García-Melero, Ana
Roig-Borrellas, Anna
Díaz-Ramos, Àngels
López-Alemany, Roser
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
α-Enolase is a key glycolytic enzyme in the cytoplasm of prokaryotic and eukaryotic cells and is considered a multifunctional protein.
α-enolase is expressed on the surface of several cell types, where it acts as a plasminogen receptor, concentrating proteolytic plasmin activity on the cell surface.
In addition to glycolytic enzyme and plasminogen receptor functions, α-Enolase appears to have other cellular functions and subcellular localizations that are distinct from its well-established function in glycolysis.
Furthermore, differential expression of α-enolase has been related to several pathologies, such as cancer, Alzheimer's disease, and rheumatoid arthritis, among others.
We have identified α-enolase as a plasminogen receptor in several cell types.
In particular, we have analyzed its role in myogenesis, as an example of extracellular remodelling process.
We have shown that α-enolase is expressed on the cell surface of differentiating myocytes, and that inhibitors of α-enolase/plasminogen binding block myogenic fusion in vitro and skeletal muscle regeneration in mice.
α-Enolase could be considered as a marker of pathological stress in a high number of diseases, performing several of its multiple functions, mainly as plasminogen receptor.
This paper is focused on the multiple roles of the α-enolase/plasminogen axis, related to several pathologies.
American Psychological Association (APA)
Díaz-Ramos, Àngels& Roig-Borrellas, Anna& García-Melero, Ana& López-Alemany, Roser. 2012. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450300
Modern Language Association (MLA)
Díaz-Ramos, Àngels…[et al.]. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-450300
American Medical Association (AMA)
Díaz-Ramos, Àngels& Roig-Borrellas, Anna& García-Melero, Ana& López-Alemany, Roser. α-Enolase, a Multifunctional Protein : Its Role on Pathophysiological Situations. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-450300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450300