Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth
Joint Authors
Park, Seok-Won
Chae, Sung-Won
Yadav, Mukesh Kumar
Song, Jae-Jun
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pneumococcal colonization and disease is often associated with biofilm formation, in which the bacteria exhibit elevated resistance both to antibiotics and to host defense systems, often resulting in infections that are persistent and difficult to treat.
We evaluated the effect of sinefungin, a nucleoside analogue of S-adenosylmethionine, on pneumococcal in vitro biofilm formation and in vivo colonization.
Sinefungin is bacteriostatic to pneumococci and significantly decreased biofilm growth and inhibited proliferation and structure of actively growing biofilms but did not alter growth or the matrix structure of established biofilms.
Sinefungin significantly reduced pneumococcal colonization in rat middle ear.
The quorum sensing molecule (autoinducer-2) production was significantly reduced by 92% in sinefungin treated samples.
The luxS, pfs, and speE genes were downregulated in biofilms grown in the presence of sinefungin.
This study shows that sinefungin inhibits pneumococcal biofilm growth in vitro and colonization in vivo, decreases AI-2 production, and downregulates luxS, pfs, and speE gene expressions.
Therefore, the S-adenosylmethionine (SAM) inhibitors could be used as lead compounds for the development of novel antibiofilm agents against pneumococci.
American Psychological Association (APA)
Yadav, Mukesh Kumar& Park, Seok-Won& Chae, Sung-Won& Song, Jae-Jun. 2014. Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-450331
Modern Language Association (MLA)
Yadav, Mukesh Kumar…[et al.]. Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-450331
American Medical Association (AMA)
Yadav, Mukesh Kumar& Park, Seok-Won& Chae, Sung-Won& Song, Jae-Jun. Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, Inhibits Streptococcus pneumoniae Biofilm Growth. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-450331
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450331