T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis
Joint Authors
Buttari, Brigitta
Riganò, Rachele
Capoano, Raffaele
Profumo, Elisabetta
Saso, Luciano
Salvati, Bruno
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Atherosclerosis has been clearly demonstrated to be a chronic inflammatory disease of the arterial wall.
Both cells of the innate and the acquired immune system, particularly monocytes and T lymphocytes, are implicated in the atherogenic process, producing different cytokines with pro- and anti-inflammatory effects.
The majority of pathogenic T cells involved in atherosclerosis are of the Th1 profile, that has been correlated positively with coronary artery disease.
Many studies conducted to evaluate the molecular factors responsible for the activation of T cells have demonstrated that the main antigenic targets in atherosclerosis are modified endogenous structures.
These self-molecules activate autoimmune reactions mainly characterized by the production of Th1 cytokines, thus sustaining the inflammatory mechanisms involved in endothelial dysfunction and plaque development.
In this paper we will summarize the different T-cell subsets involved in atherosclerosis and the best characterized autoantigens involved in cardiovascular inflammation.
American Psychological Association (APA)
Profumo, Elisabetta& Buttari, Brigitta& Saso, Luciano& Capoano, Raffaele& Salvati, Bruno& Riganò, Rachele. 2012. T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450392
Modern Language Association (MLA)
Profumo, Elisabetta…[et al.]. T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis. The Scientific World Journal No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450392
American Medical Association (AMA)
Profumo, Elisabetta& Buttari, Brigitta& Saso, Luciano& Capoano, Raffaele& Salvati, Bruno& Riganò, Rachele. T Lymphocyte Autoreactivity in Inflammatory Mechanisms Regulating Atherosclerosis. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450392
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450392