Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa : Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen
Joint Authors
Sanne, Ian
Fox, Matthew P.
Takuva, Simbarashe
Maskew, Mhairi
Brennan, Alana T.
MacPhail, A. Patrick
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Among those with HIV, anemia is a strong risk factor for disease progression and death independent of CD4 count and viral load.
Understanding the role of anemia in HIV treatment is critical to developing strategies to reduce morbidity and mortality.
We conducted a prospective analysis among 10,259 HIV-infected adults initiating first-line ART between April 2004 and August 2009 in Johannesburg, South Africa.
The prevalence of anemia at ART initiation was 25.8%.
Mean hemoglobin increased independent of baseline CD4.
Females, lower BMI, WHO stage III/IV, lower CD4 count, and zidovudine use were associated with increased risk of developing anemia during follow-up.
After initiation of ART, hemoglobin improved, regardless of regimen type and the degree of immunosuppression.
Between 0 and 6 months on ART, the magnitude of hemoglobin increase was linearly related to CD4 count.
However, between 6 and 24 months on ART, hemoglobin levels showed a sustained overall increase, the magnitude of which was similar regardless of baseline CD4 level.
This increase in hemoglobin was seen even among patients on zidovudine containing regimens.
Since low hemoglobin is an established adverse prognostic marker, prompt identification of anemia may result in improved morbidity and mortality of patients initiating ART.
American Psychological Association (APA)
Takuva, Simbarashe& Maskew, Mhairi& Brennan, Alana T.& Sanne, Ian& MacPhail, A. Patrick& Fox, Matthew P.. 2013. Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa : Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen. Journal of Tropical Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450875
Modern Language Association (MLA)
Takuva, Simbarashe…[et al.]. Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa : Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen. Journal of Tropical Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-450875
American Medical Association (AMA)
Takuva, Simbarashe& Maskew, Mhairi& Brennan, Alana T.& Sanne, Ian& MacPhail, A. Patrick& Fox, Matthew P.. Anemia among HIV-Infected Patients Initiating Antiretroviral Therapy in South Africa : Improvement in Hemoglobin regardless of Degree of Immunosuppression and the Initiating ART Regimen. Journal of Tropical Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-450875
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450875