Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes.
Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells.
Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure.
Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling.
In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.
American Psychological Association (APA)
2012. Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987
Modern Language Association (MLA)
Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450987
American Medical Association (AMA)
Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-450987