Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity

Source

PPAR Research

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-09-06

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Natural & Life Sciences (Multidisciplinary)
Biology

Abstract EN

The nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) is required for differentiation and function of mature adipocytes.

Its expression is induced during adipogenesis where it plays a key role in establishing the transcriptome of terminally differentiated white fat cells.

Here, we review findings indicating that PPARγ expression and activity are intricately regulated through control of chromatin structure.

Hierarchical and combinatorial activation of transcription factors, noncoding RNAs, and chromatin remodelers allows for temporally controlled expression of PPARγ and its target genes through sequential chromatin remodelling.

In obesity, these regulatory pathways may be altered and lead to modified PPARγ activity.

American Psychological Association (APA)

2012. Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987

Modern Language Association (MLA)

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-450987

American Medical Association (AMA)

Coordinated Regulation of PPARγ Expression and Activity through Control of Chromatin Structure in Adipogenesis and Obesity. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-450987

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-450987