Statins as Modulators of Regulatory T-Cell Biology
Joint Authors
Gutierrez, Fredy R. S.
Forero-Peña, David A.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol.
Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms.
On the other hand, the induction and activity of regulatory T cells (Treg) are key processes in the prevention of pathology during chronic inflammatory and autoimmune diseases.
Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers.
The potential effects of statins on the biology of Treg are of particular importance because of their eventual application as in vivo inducers of Treg in the treatment of multiple conditions.
In this paper we review the experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions and discuss its potential clinical significance.
American Psychological Association (APA)
Forero-Peña, David A.& Gutierrez, Fredy R. S.. 2013. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451185
Modern Language Association (MLA)
Forero-Peña, David A.& Gutierrez, Fredy R. S.. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-451185
American Medical Association (AMA)
Forero-Peña, David A.& Gutierrez, Fredy R. S.. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451185
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451185