Statins as Modulators of Regulatory T-Cell Biology

Joint Authors

Gutierrez, Fredy R. S.
Forero-Peña, David A.

Source

Mediators of Inflammation

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-10-03

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Statins are pharmacological inhibitors of the activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR), an enzyme responsible for the synthesis of cholesterol.

Some recent experimental studies have shown that besides their effects on the primary and secondary prevention of cardiovascular diseases, statins may also have beneficial anti-inflammatory effects through diverse mechanisms.

On the other hand, the induction and activity of regulatory T cells (Treg) are key processes in the prevention of pathology during chronic inflammatory and autoimmune diseases.

Hence, strategies oriented towards the therapeutic expansion of Tregs are gaining special attention among biomedical researchers.

The potential effects of statins on the biology of Treg are of particular importance because of their eventual application as in vivo inducers of Treg in the treatment of multiple conditions.

In this paper we review the experimental evidence pointing out to a potential effect of statins on the role of regulatory T cells in different conditions and discuss its potential clinical significance.

American Psychological Association (APA)

Forero-Peña, David A.& Gutierrez, Fredy R. S.. 2013. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451185

Modern Language Association (MLA)

Forero-Peña, David A.& Gutierrez, Fredy R. S.. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-451185

American Medical Association (AMA)

Forero-Peña, David A.& Gutierrez, Fredy R. S.. Statins as Modulators of Regulatory T-Cell Biology. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-451185

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-451185