PPARγ Promotes Growth and Invasion of Thyroid Cancer Cells
Joint Authors
Schweppe, Rebecca E.
Zhou, Qiong
Fretwell, Deborah L.
Wood, William M.
Bauerle, Kevin T.
Pike, Laura A.
Haugen, Bryan R.
Sharma, Vibha
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Undifferentiated (anaplastic) thyroid cancer (ATC) is one of the most aggressive human malignancies and no effective therapy is currently available.
We show here that PPARγ levels are elevated in cells derived from ATC.
Depletion of PPARγ in HTh74 ATC cells resulted in decreased cell growth, cell cycle arrest and a reduction in pRb and cyclin A and B1 levels.
We further showed that both flank and orthotopic thyroid tumors derived from PPARγ-depleted cells grew more slowly than PPARγ-expressing cells.
When PPARγ was overexpressed in more differentiated thyroid cancer BCPAP cells which lack PPARγ, there was increased growth and raised pRb and cyclin A and B1 levels.
Finally, PPARγ depletion in ATC cells decreased their invasive capacity whereas overexpression in PTC cells increased invasiveness.
These data suggest that PPARγ may play a detrimental role in thyroid cancer and that targeting it therapeutically may lead to improved treatment of advanced thyroid cancer.
American Psychological Association (APA)
Wood, William M.& Sharma, Vibha& Bauerle, Kevin T.& Pike, Laura A.& Zhou, Qiong& Fretwell, Deborah L.…[et al.]. 2011. PPARγ Promotes Growth and Invasion of Thyroid Cancer Cells. PPAR Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451602
Modern Language Association (MLA)
Wood, William M.…[et al.]. PPARγ Promotes Growth and Invasion of Thyroid Cancer Cells. PPAR Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-451602
American Medical Association (AMA)
Wood, William M.& Sharma, Vibha& Bauerle, Kevin T.& Pike, Laura A.& Zhou, Qiong& Fretwell, Deborah L.…[et al.]. PPARγ Promotes Growth and Invasion of Thyroid Cancer Cells. PPAR Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-451602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451602