Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK
Joint Authors
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Hepatocellular carcinoma (HCC) is the third most common cause of cancer mortality.
Short-term prognosis of patients with HCC has improved recently due to advances in early diagnosis and treatment, but long-term prognosis is still unsatisfactory.
Therefore, obtaining a further understanding of the molecular carcinogenic mechanisms and the unique pathogenic biology of HCC is important.
The most characteristic process in hepatocarcinogenesis is underlying chronic liver injury, which leads to repeated cycles of hepatocyte death, inflammation, and compensatory proliferation and subsequently provides a mitogenic and mutagenic environment leading to the development of HCC.
Recent in vivo studies have shown that the stress-activated mitogen-activated protein kinase (MAPK) cascade converging on c-Jun NH2-terminal kinase (JNK) and p38 plays a central role in these processes, and it has attracted considerable attention as a therapeutic target.
However, JNK and p38 have complex functions and a wide range of cellular effects.
In addition, crosstalk with each other and the nuclear factor-kappaB pathway further complicate these functions.
A full understanding is essential to bring these observations into clinical settings.
In this paper, we discuss the latest findings regarding the mechanisms of liver injury and hepatocarcinogenesis focusing on the role of the stress-activated MAPK pathway.
American Psychological Association (APA)
Nakagawa, Hayato& Maeda, Shin. 2012. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-451693
Modern Language Association (MLA)
Nakagawa, Hayato& Maeda, Shin. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-451693
American Medical Association (AMA)
Nakagawa, Hayato& Maeda, Shin. Molecular Mechanisms of Liver Injury and Hepatocarcinogenesis : Focusing on the Role of Stress-Activated MAPK. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-451693
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451693