Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration
Joint Authors
Barud, Hernane da Silva
Saska, Sybele
Ribeiro, Sidney J. L.
Gaspar, Ana Maria Minarelli
Messaddeq, Y.
Marchetto, R.
Source
International Journal of Biomaterials
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to develop and to evaluate the biological properties of bacterial cellulose-hydroxyapatite (BC-HA) nanocomposite membranes for bone regeneration.
Nanocomposites were prepared from bacterial cellulose membranes sequentially incubated in solutions of CaCl2 followed by Na2HPO4.
BC-HA membranes were evaluated in noncritical bone defects in rat tibiae at 1, 4, and 16 weeks.
Thermogravimetric analyses showed that the amount of the mineral phase was 40%–50% of the total weight.
Spectroscopy, electronic microscopy/energy dispersive X-ray analyses, and X-ray diffraction showed formation of HA crystals on BC nanofibres.
Low crystallinity HA crystals presented Ca/P a molar ratio of 1.5 (calcium-deficient HA), similar to physiological bone.
Fourier transformed infrared spectroscopy analysis showed bands assigned to phosphate and carbonate ions.
In vivo tests showed no inflammatory reaction after 1 week.
After 4 weeks, defects were observed to be completely filled in by new bone tissue.
The BC-HA membranes were effective for bone regeneration.
American Psychological Association (APA)
Saska, Sybele& Barud, Hernane da Silva& Gaspar, Ana Maria Minarelli& Marchetto, R.& Ribeiro, Sidney J. L.& Messaddeq, Y.. 2011. Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration. International Journal of Biomaterials،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451947
Modern Language Association (MLA)
Saska, Sybele…[et al.]. Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration. International Journal of Biomaterials No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-451947
American Medical Association (AMA)
Saska, Sybele& Barud, Hernane da Silva& Gaspar, Ana Maria Minarelli& Marchetto, R.& Ribeiro, Sidney J. L.& Messaddeq, Y.. Bacterial Cellulose-Hydroxyapatite Nanocomposites for Bone Regeneration. International Journal of Biomaterials. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-451947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451947
