Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome
Joint Authors
Matsumoto, Toshio
Akaike, Masashi
Ikeda, Yasumasa
Yagi, Shusuke
Aihara, Ken Ichi
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Transforming growth factor-β1 (TGF-β1) is a polypeptide member of the transforming growth factor β superfamily of cytokines.
It is a secreted protein that performs many cellular functions including control of cell growth, cell proliferation, cell differentiation and apoptosis.
In the cardiovascular system, TGF-β1 plays pivotal roles in the pathogenesis of hypertension, restenosis after percutaneous coronary intervention, atherosclerosis, cardiac hypertrophy and heart failure.
In addition, TGF-β1 has been shown to be increased in adipose tissue of obese subjects with insulin resistance.
Furthermore, TGF-β1 is a potent initiator of proliferation of renal mesangial cells leading to chronic kidney disease.
Some currently available agents can manipulate TGF-β1 expression leading to amelioration of cardiovascular diseases.
Thus, an understanding of interactions between chronic kidney disease and metabolic syndrome and the development of cardiovascular diseases is an important issue, and attention should be given to TGF-β1 as a crucial factor for regulation and modulation of those pathological conditions.
American Psychological Association (APA)
Aihara, Ken Ichi& Ikeda, Yasumasa& Yagi, Shusuke& Akaike, Masashi& Matsumoto, Toshio. 2010. Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451950
Modern Language Association (MLA)
Aihara, Ken Ichi…[et al.]. Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome. Cardiology Research and Practice No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-451950
American Medical Association (AMA)
Aihara, Ken Ichi& Ikeda, Yasumasa& Yagi, Shusuke& Akaike, Masashi& Matsumoto, Toshio. Transforming Growth Factor-β1 as a Common Target Molecule for Development of Cardiovascular Diseases, Renal Insufficiency and Metabolic Syndrome. Cardiology Research and Practice. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-451950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-451950