The Role of Sexually Transmitted Infections in HIV-1 Progression : A Comprehensive Review of the Literature
Joint Authors
Chun, Helen M.
Macalino, Grace E.
Carpenter, Robert J.
Crum-Cianflone, Nancy F.
Source
Journal of Sexually Transmitted Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Due to shared routes of infection, HIV-infected persons are frequently coinfected with other sexually transmitted infections (STIs).
Studies have demonstrated the bidirectional relationships between HIV and several STIs, including herpes simplex virus-2 (HSV-2), hepatitis B and C viruses, human papilloma virus, syphilis, gonorrhea, chlamydia, and trichomonas.
HIV-1 may affect the clinical presentation, treatment outcome, and progression of STIs, such as syphilis, HSV-2, and hepatitis B and C viruses.
Likewise, the presence of an STI may increase both genital and plasma HIV-1 RNA levels, enhancing the transmissibility of HIV-1, with important public health implications.
Regarding the effect of STIs on HIV-1 progression, the most studied interrelationship has been with HIV-1/HSV-2 coinfection, with recent studies showing that antiherpetic medications slow the time to CD4 <200 cells/µL and antiretroviral therapy among coinfected patients.
The impact of other chronic STIs (hepatitis B and C) on HIV-1 progression requires further study, but some studies have shown increased mortality rates.
Treatable, nonchronic STIs (i.e., syphilis, gonorrhea, chlamydia, and trichomonas) typically have no or transient impacts on plasma HIV RNA levels that resolve with antimicrobial therapy; no long-term effects on outcomes have been shown.
Future studies are advocated to continue investigating the complex interplay between HIV-1 and other STIs.
American Psychological Association (APA)
Chun, Helen M.& Carpenter, Robert J.& Macalino, Grace E.& Crum-Cianflone, Nancy F.. 2013. The Role of Sexually Transmitted Infections in HIV-1 Progression : A Comprehensive Review of the Literature. Journal of Sexually Transmitted Diseases،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-452041
Modern Language Association (MLA)
Chun, Helen M.…[et al.]. The Role of Sexually Transmitted Infections in HIV-1 Progression : A Comprehensive Review of the Literature. Journal of Sexually Transmitted Diseases No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-452041
American Medical Association (AMA)
Chun, Helen M.& Carpenter, Robert J.& Macalino, Grace E.& Crum-Cianflone, Nancy F.. The Role of Sexually Transmitted Infections in HIV-1 Progression : A Comprehensive Review of the Literature. Journal of Sexually Transmitted Diseases. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-452041
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452041