p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway
Joint Authors
Song, Yang
Liang, Xianmin
Cheng, Jin
Guan, Xia
Wang, Yinan
Hu, Yafei
Yang, Kedi
Shi, Yuqin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
One,1-dichloro-2,2 bis(p-chlorophenyl) ethylene (p,p′-DDE), the major metabolite of 2,2-bis(4-Chlorophenyl)-1,1,1-trichloroethane (DDT), is a known persistent organic pollutant and male reproductive toxicant.
It has antiandrogenic effect.
However, the mechanism by which p,p′-DDE exposure causes male reproductive toxicity remains unknown.
In the present study, rat Sertoli cells were used to investigate the molecular mechanism involved in p,p′-DDE-induced toxicity in male reproductive system.
The results indicated that p,p′-DDE exposure at over 30 μM showed the induction of apoptotic cell death.
p,p′-DDE could induce increases in FasL mRNA and protein, which could be blocked by an antioxidant agent, N-acetyl-l-cysteine (NAC).
In addition, caspase-3 and -8 were activated by p,p′-DDE treatment in these cells.
The activation of NF-κB was enhanced with the increase of p,p′-DDE dose.
Taken together, these results suggested that exposure to p,p′-DDE might induce apoptosis of rat Sertoli cells through a FasL-dependent pathway.
American Psychological Association (APA)
Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. 2009. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-452409
Modern Language Association (MLA)
Shi, Yuqin…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-452409
American Medical Association (AMA)
Shi, Yuqin& Song, Yang& Wang, Yinan& Liang, Xianmin& Hu, Yafei& Guan, Xia…[et al.]. p,p′-DDE Induces Apoptosis of Rat Sertoli Cells via a FasL-Dependent Pathway. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-452409
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452409