Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients
Joint Authors
Alexandrou, Andreas
Creatsas, George
Iliodromiti, Zoe
Daniilidis, Angelos
Varras, Michail
Lambrinoudaki, Irene
Augoulea, Areti
Vrachnis, Nicolaos
Dafopoulos, Konstantinos
Deligeoroglou, Efthymios
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Atherosclerosis is the principal cause of cardiovascular disease (CVD) and has many risk factors, among which is diabetes.
Osteoprotegerin (OPG) is a soluble glycoprotein, involved in bone metabolism.
OPG is also found in other tissues, and studies have shown that it is expressed in vascular smooth muscle cells.
OPG has been implicated in various inflammations and also has been linked to diabetes mellitus.
Increased serum OPG levels were found in patients with diabetes and poor glycemic control.
Furthermore, prepubertal children with type 1 diabetes have significantly increased OPG levels.
Receptor activator of nuclear factor kappa-B ligand (RANKL) is not found in the vasculature in normal conditions, but may appear in calcifying areas.
OPG and RANKL are important regulators of mineral metabolism in both bone and vascular tissues.
Few data are available on the relationship between plasma OPG/RANKL levels and endothelial dysfunction as assessed using noninvasive methods like ultrasound indexes, neither in the general population nor, more specifically, in diabetic patients.
The aim of our review study was to investigate, based on the existing data, these interrelationships in order to identify a means of predicting, via noninvasive methods, later development of endothelial dysfunction and vascular complications in diabetic patients.
American Psychological Association (APA)
Augoulea, Areti& Vrachnis, Nicolaos& Lambrinoudaki, Irene& Dafopoulos, Konstantinos& Iliodromiti, Zoe& Daniilidis, Angelos…[et al.]. 2013. Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452477
Modern Language Association (MLA)
Augoulea, Areti…[et al.]. Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients. International Journal of Endocrinology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-452477
American Medical Association (AMA)
Augoulea, Areti& Vrachnis, Nicolaos& Lambrinoudaki, Irene& Dafopoulos, Konstantinos& Iliodromiti, Zoe& Daniilidis, Angelos…[et al.]. Osteoprotegerin as a Marker of Atherosclerosis in Diabetic Patients. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-452477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452477