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Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand
Joint Authors
Ilyinsky, Nikolay S.
Shtil, Alexander A.
Kaluzhny, Dmitry N.
Borisova, Olga F.
Shchyolkina, Anna K.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The indolocarbazole derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) has demonstrated a high potency (at nanomolar to submicromolar concentrations) towards the NCI panel of human tumor cell lines and transplanted tumors.
Intercalation into the DNA double helix has been identified as an important prerequisite for AIC cytotoxicity.
In this study, we provide evidence for preferential binding to the G-quadruplex derived from the c-Myc oncogene promoter (Pu18 d(AG3TG4)2; G-c-Myc).
The association constant for AIC:G-c-Myc complex was ~100 times and 10 times greater than the respective values for the complexes AIC:c-Myc duplex and AIC:telomeric d(TTAGGG)4 G-quadruplex.
The concentrations at which AIC formed complexes with G-c-Myc were close to those that attenuated the steady-state level of the c-Myc mRNA in the human HCT116 colon carcinoma cell line.
We suggest that preferential binding of AIC to G-c-Myc rather than to the c-Myc duplex might favor the quadruplex formation in the cells, thereby contributing to downregulation of the c-Myc expression by AIC.
American Psychological Association (APA)
Kaluzhny, Dmitry N.& Shchyolkina, Anna K.& Ilyinsky, Nikolay S.& Borisova, Olga F.& Shtil, Alexander A.. 2011. Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand. Journal of Nucleic Acids،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452711
Modern Language Association (MLA)
Kaluzhny, Dmitry N.…[et al.]. Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand. Journal of Nucleic Acids No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-452711
American Medical Association (AMA)
Kaluzhny, Dmitry N.& Shchyolkina, Anna K.& Ilyinsky, Nikolay S.& Borisova, Olga F.& Shtil, Alexander A.. Novel Indolocarbazole Derivative 12-(α-L-arabinopyranosyl)indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7-dione Is a Preferred c-Myc Guanine Quadruplex Ligand. Journal of Nucleic Acids. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-452711
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452711