Functional Promiscuity of Homologues of the Bacterial ArsA ATPases
Joint Authors
Castillo, Rostislav
Saier, Milton H.
Source
International Journal of Microbiology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-20
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Abstract EN
The ArsA ATPase of E.
coli plays an essential role in arsenic detoxification.
Published evidence implicates ArsA in the energization of As(III) efflux via the formation of an oxyanion-translocating complex with ArsB.
In addition, eukaryotic ArsA homologues have several recognized functions unrelated to arsenic resistance.
By aligning ArsA homologues, constructing phylogenetic trees, examining ArsA encoding operons, and estimating the probable coevolution of these homologues with putative transporters and auxiliary proteins unrelated to ArsB, we provide evidence for new functions for ArsA homologues.
They may play roles in carbon starvation, gas vesicle biogenesis, and arsenic resistance.
The results lead to the proposal that ArsA homologues energize four distinct and nonhomologous transporters, ArsB, ArsP, CstA, and Acr3.
American Psychological Association (APA)
Castillo, Rostislav& Saier, Milton H.. 2010. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. International Journal of Microbiology،Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-452978
Modern Language Association (MLA)
Castillo, Rostislav& Saier, Milton H.. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. International Journal of Microbiology No. 2010 (2010), pp.1-21.
https://search.emarefa.net/detail/BIM-452978
American Medical Association (AMA)
Castillo, Rostislav& Saier, Milton H.. Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. International Journal of Microbiology. 2010. Vol. 2010, no. 2010, pp.1-21.
https://search.emarefa.net/detail/BIM-452978
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452978