Alternative Macroautophagic Pathways

Abstract EN

Macroautophagy is a bulk degradation process that mediates the clearance of long-lived proteins, aggregates, or even whole organelles.

This process includes the formation of autophagosomes, double-membrane structures responsible for delivering cargo to lysosomes for degradation.

Currently, other alternative autophagy pathways have been described, which are independent of macroautophagic key players like Atg5 and Beclin 1 or the lipidation of LC3.

In this review, we highlight recent insights in indentifying and understanding the molecular mechanism responsible for alternative autophagic pathways.