Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation
Joint Authors
Christoforidis, John Byron
Agrawal, Shivi
Joshi, Malav
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The pathogenesis of idiopathic epiretinal membranes (iERMs), a common pathology found in retina clinics, still eludes researchers to date.
Ultrastructural studies of iERMs in the past have failed to identify the cells of origin due to the striking morphologic changes of cells involved via transdifferentiation.
Thus, immunohistochemical techniques that stain for the cytostructural components of cells have confirmed the importance of glial cells and hyalocytes in iERM formation.
The cellular constituents of iERMs are thought to consist of glial cells, fibroblasts, hyalocytes, etc.
that, in concert with cytokines and growth factors present in the vitreous, lead to iERM formation.
Recently, research has focused on the role of the posterior hyaloid in iERM formation and contraction, particularly the process of anomalous PVD as it relates to iERM formation.
Recent advances in proteomics techniques have also elucidated the growth factors and cytokines involved in iERM formation, most notably nerve growth factor, glial cell line-derived growth factor, and transforming growth factor β1.
American Psychological Association (APA)
Joshi, Malav& Agrawal, Shivi& Christoforidis, John Byron. 2013. Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453332
Modern Language Association (MLA)
Joshi, Malav…[et al.]. Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453332
American Medical Association (AMA)
Joshi, Malav& Agrawal, Shivi& Christoforidis, John Byron. Inflammatory Mechanisms of Idiopathic Epiretinal Membrane Formation. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453332
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453332