Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels
Joint Authors
Sun, Chun-Chin
Lee, Jenn-Kuen
Wang, Mei-Chun
Lu, Chih-Chen
Chu, Chih-Hsun
Chuang, Ming-Ju
Lam, Hing-Chung
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-18
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
To evaluate the relationship between circulating adiponectin and insulin sensitivity in patients with hyperthyroid Graves' disease, we studied 19 adult patients with this disease and 19 age- and sex-matched euthyroid controls.
All hyperthyroid patients were treated with antithyroid drugs and were re-evaluated after thyroid function normalized.
Before antithyroid treatment, the adiponectin plasma concentrations were not different comparing with those in control group.
The adiponectin levels remained unchanged after treatment.
The homeostasis model assessment of insulin resistance (HOMA-IR) in hyperthyroid group was higher before treatment than after treatment.
There was no significant difference in serum glucose and insulin levels between hyperthyroid and control groups and in the hyperthyroid group before and after treatment.
BMI-adjusted adiponectin levels were not different among three groups.
On the other hand, BMI-adjusted insulin levels and HOMA-IR values were significantly decreased after management of hyperthyroidism.
Pearson's correlation revealed that insulin and HOMA-IR values positively correlated with triiodothyronine (T3) and free thyroxine (FT4) levels.
However, adiponectin did not correlate with T3, FT4, insulin, HOMA-IR and thyrotropin receptor autoantibody (TRAb) levels.
In conclusion, insulin resistance associated with hyperthyroidism is not mediated by the levels of plasma adiponectin.
American Psychological Association (APA)
Chu, Chih-Hsun& Lam, Hing-Chung& Lee, Jenn-Kuen& Lu, Chih-Chen& Sun, Chun-Chin& Wang, Mei-Chun…[et al.]. 2011. Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels. Journal of Thyroid Research،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-453542
Modern Language Association (MLA)
Chu, Chih-Hsun…[et al.]. Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels. Journal of Thyroid Research No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-453542
American Medical Association (AMA)
Chu, Chih-Hsun& Lam, Hing-Chung& Lee, Jenn-Kuen& Lu, Chih-Chen& Sun, Chun-Chin& Wang, Mei-Chun…[et al.]. Hyperthyroidism-Associated Insulin Resistance Is Not Mediated by Adiponectin Levels. Journal of Thyroid Research. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-453542
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453542