Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats
Joint Authors
Hayashida, Kayoko
Uekama, Kaneto
Pipkin, James D.
Anno, Takayuki
Arima, Hidetoshi
Ono, Naomi
Higashi, Taishi
Motoyama, Keiichi
Uehata, Keiko
Hirayama, Fumitoshi
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-11
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Insulin glargine is a synthetic long-acting insulin product used for patients with diabetes mellitus.
In this study, to obtain the further desirable blood-glucose lowering profile of insulin glargine, we investigated the effects of β-cyclodextrin sulfate (Sul-β-CyD) and sulfobutylether β-cyclodextrin (SBE7-β-CyD) on physicochemical properties of insulin glargine and pharmacokinetics/pharmacodynamics of insulin glargine after subcutaneous injection to rats.
Sul-β-CyD and SBE7-β-CyD increased solubility of insulin glargine.
SBE7-β-CyD suppressed the formation of oligomer and enhanced the dissolution rate of insulin glargine from its precipitate, compared to that of Sul-β-CyD.
Additionally, we revealed that after subcutaneous administration of an insulin glargine solution, SBE7-β-CyD, but not Sul-β-CyD, increased bioavailability and sustained the blood-glucose lowering effect, possibly due to the inhibitory effects of SBE7-β-CyD on the enzymatic degradation at the injection site.
These results suggest that SBE7-β-CyD could be a useful excipient for sustained release of insulin glargine.
American Psychological Association (APA)
Uehata, Keiko& Anno, Takayuki& Hayashida, Kayoko& Motoyama, Keiichi& Higashi, Taishi& Hirayama, Fumitoshi…[et al.]. 2011. Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats. Journal of Drug Delivery،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453580
Modern Language Association (MLA)
Uehata, Keiko…[et al.]. Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats. Journal of Drug Delivery No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-453580
American Medical Association (AMA)
Uehata, Keiko& Anno, Takayuki& Hayashida, Kayoko& Motoyama, Keiichi& Higashi, Taishi& Hirayama, Fumitoshi…[et al.]. Effects of Selected Anionic β-Cyclodextrins on Persistence of Blood Glucose Lowering by Insulin Glargine after Subcutaneous Injection to Rats. Journal of Drug Delivery. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453580