Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes
Joint Authors
Rutella, Sergio
Locatelli, Franco
Source
Clinical and Developmental Immunology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Multiple myeloma (MM) is a plasma cell malignancy associated with high levels of monoclonal (M) protein in the blood and/or serum.
MM can occur de novo or evolve from benign monoclonal gammopathy of undetermined significance (MGUS).
Current translational research into MM focuses on the development of combination therapies directed against molecularly defined targets and that are aimed at achieving durable clinical responses.
MM cells have a unique ability to evade immunosurveillance through several mechanisms including, among others, expansion of regulatory T cells (Treg), reduced T-cell cytotoxic activity and responsiveness to IL-2, defects in B-cell immunity, and induction of dendritic cell (DC) dysfunction.
Immune defects could be a major cause of failure of the recent immunotherapy trials in MM.
This article summarizes our current knowledge on the molecular determinants of immune evasion in patients with MM and highlights how these pathways can be targeted to improve patients’ clinical outcome.
American Psychological Association (APA)
Rutella, Sergio& Locatelli, Franco. 2012. Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-453655
Modern Language Association (MLA)
Rutella, Sergio& Locatelli, Franco. Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes. Clinical and Developmental Immunology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-453655
American Medical Association (AMA)
Rutella, Sergio& Locatelli, Franco. Targeting Multiple-Myeloma-Induced Immune Dysfunction to Improve Immunotherapy Outcomes. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-453655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453655