Small Changes Huge Impact : The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease
Joint Authors
Cheema, Amrita K.
Karve, Tejaswita M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Posttranslational modifications (PTMs) modulate protein function in most eukaryotes and have a ubiquitous role in diverse range of cellular functions.
Identification, characterization, and mapping of these modifications to specific amino acid residues on proteins are critical towards understanding their functional significance in a biological context.
The interpretation of proteome data obtained from the high-throughput methods cannot be deciphered unambiguously without a priori knowledge of protein modifications.
An in-depth understanding of protein PTMs is important not only for gaining a perception of a wide array of cellular functions but also towards developing drug therapies for many life-threatening diseases like cancer and neurodegenerative disorders.
Many of the protein modifications like ubiquitination play a decisive role in various drug response(s) and eventually in disease prognosis.
Thus, many commonly observed PTMs are routinely tracked as disease markers while many others are used as molecular targets for developing target-specific therapies.
In this paper, we summarize some of the major, well-studied protein alterations and highlight their importance in various chronic diseases and normal development.
In addition, other promising minor modifications such as SUMOylation, observed to impact cellular dynamics as well as disease pathology, are mentioned briefly.
American Psychological Association (APA)
Karve, Tejaswita M.& Cheema, Amrita K.. 2011. Small Changes Huge Impact : The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease. Journal of Amino Acids،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-454583
Modern Language Association (MLA)
Karve, Tejaswita M.& Cheema, Amrita K.. Small Changes Huge Impact : The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease. Journal of Amino Acids No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-454583
American Medical Association (AMA)
Karve, Tejaswita M.& Cheema, Amrita K.. Small Changes Huge Impact : The Role of Protein Posttranslational Modifications in Cellular Homeostasis and Disease. Journal of Amino Acids. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-454583
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454583