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Nuclear Transport : A Switch for the Oxidative Stress—Signaling Circuit?
Joint Authors
Stochaj, Ursula
Kodiha, Mohamed
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Imbalances in the formation and clearance of reactive oxygen species (ROS) can lead to oxidative stress and subsequent changes that affect all aspects of physiology.
To limit and repair the damage generated by ROS, cells have developed a multitude of responses.
A hallmark of these responses is the activation of signaling pathways that modulate the function of downstream targets in different cellular locations.
To this end, critical steps of the stress response that occur in the nucleus and cytoplasm have to be coordinated, which makes the proper communication between both compartments mandatory.
Here, we discuss the interdependence of ROS-mediated signaling and the transport of macromolecules across the nuclear envelope.
We highlight examples of oxidant-dependent nuclear trafficking and describe the impact of oxidative stress on the transport apparatus.
Our paper concludes by proposing a cellular circuit of ROS-induced signaling, nuclear transport and repair.
American Psychological Association (APA)
Kodiha, Mohamed& Stochaj, Ursula. 2011. Nuclear Transport : A Switch for the Oxidative Stress—Signaling Circuit?. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-454673
Modern Language Association (MLA)
Kodiha, Mohamed& Stochaj, Ursula. Nuclear Transport : A Switch for the Oxidative Stress—Signaling Circuit?. Journal of Signal Transduction No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-454673
American Medical Association (AMA)
Kodiha, Mohamed& Stochaj, Ursula. Nuclear Transport : A Switch for the Oxidative Stress—Signaling Circuit?. Journal of Signal Transduction. 2011. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-454673
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454673