Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding
Joint Authors
Migliore, Maria Rita
Di Renzo, Laura
Carbonelli, Maria Grazia
Rillo, Guido
Di Daniele, Nicola
Iacopino, Leonardo
Bianchi, Alessia
De Lorenzo, Antonino
Domino, Emidio
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Recent data demonstrated that the −174 G>C IL-6 polymorphism may account for differences in the therapeutic response to laparoscopic adjustable gastric banding (LAGB) surgery.
Objective.
We investigated the impact of −174 G>C IL-6 polymorphism on weight loss, body composition, and fluid distribution changes in obese subjects after LAGB.
Design and Outcome Measures.
Twenty obese subjects were selected and studied at baseline and 3 months after LAGB.
Genetic assessment of −174 G>C IL-6 polymorphism and anthropometric and bioelectrical impedance analysis were performed.
Results.
At baseline, C(+) carriers had a lower extracellular water (ECW) and higher intra-CW, phase angle (PA), reactance Xc, and Xc/height.
LAGB surgery determined significant reductions in weight and BMI.
After LAGB, in C(−) carriers, significant decreases in weight, BMI, and ECW and increases in BCM, BCMI, ICW, PA, and Xc/H were highlighted.
In C(+) carriers, significant reductions in weight, BMI, ICW, and PA and increases in ECW, Na/K, resistance (R), and R/height were obtained.
Significant higher reductions in BMI and Xc/H were observed in C(+) with respect to C(−) carriers.
Conclusions.
Genotyping of genetic variants, for example, the −174 G>C polymorphism of IL-6, gives the opportunity to predict therapeutic response, in terms of body composition outcomes after LAGB.
American Psychological Association (APA)
Di Renzo, Laura& Carbonelli, Maria Grazia& Bianchi, Alessia& Domino, Emidio& Migliore, Maria Rita& Rillo, Guido…[et al.]. 2012. Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding. Journal of Obesity،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454696
Modern Language Association (MLA)
Di Renzo, Laura…[et al.]. Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding. Journal of Obesity No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-454696
American Medical Association (AMA)
Di Renzo, Laura& Carbonelli, Maria Grazia& Bianchi, Alessia& Domino, Emidio& Migliore, Maria Rita& Rillo, Guido…[et al.]. Impact of the −174 G > C IL-6 Polymorphism on Bioelectrical Parameters in Obese Subjects after Laparoscopic Adjustable Gastric Banding. Journal of Obesity. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-454696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454696