To Live or to Die : Prosurvival Activity of PPARγ in Cancers
Joint Authors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-09-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The role of PPARγ in tumorigenesis is controversial.
In this article, we review and analyze literature from the past decade that highlights the potential proneoplastic activity of PPARγ.
We discuss the following five aspects of the nuclear hormone receptor and its agonists: (1) relative expression of PPARγ in human tumor versus normal tissues; (2) receptor-dependent proneoplastic effects; (3) impact of PPARγ and its agonists on tumors in animal models; (4) clinical trials of thiazolidinediones (TZDs) in human malignancies; (5) TZDs as chemopreventive agents in epidemiology studies.
The focus is placed on the most relevant in vivo animal models and human data.
In vitro cell line studies are included only when the effects are shown to be dependent on the PPARγ receptor.
American Psychological Association (APA)
Wang, Y. Lynn& Miao, Qi. 2008. To Live or to Die : Prosurvival Activity of PPARγ in Cancers. PPAR Research،Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-454772
Modern Language Association (MLA)
Wang, Y. Lynn& Miao, Qi. To Live or to Die : Prosurvival Activity of PPARγ in Cancers. PPAR Research No. 2008 (2008), pp.1-13.
https://search.emarefa.net/detail/BIM-454772
American Medical Association (AMA)
Wang, Y. Lynn& Miao, Qi. To Live or to Die : Prosurvival Activity of PPARγ in Cancers. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-13.
https://search.emarefa.net/detail/BIM-454772
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454772