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α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies
Joint Authors
Fujikake, Nobuhiro
Nagai, Yoshitaka
Mizuno, Hideya
Wada, Keiji
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-20
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
α-Synuclein (α-Syn) is a major component of protein inclusions known as Lewy bodies, which are hallmarks of synucleinopathies such as Parkinson's disease (PD).
The α-Syn gene is one of the familial PD-causing genes and is also associated with an increased risk of sporadic PD.
Numerous studies using α-Syn expressing transgenic animals have indicated that α-Syn plays a critical role in the common pathogenesis of synucleinopathies.
Drosophila melanogaster has several advantages for modeling human neurodegenerative diseases and is widely used for studying their pathomechanisms and therapies.
In fact, Drosophila models expressing α-Syn have already been established and proven to replicate several features of human PD.
In this paper, we review the current research on synucleinopathies using α-Syn Drosophila models and, moreover, explore the possibilities of these models for comprehensive genetic analyses and large-scale drug screening towards elucidating the molecular pathogenesis and developing therapies for synucleinopathies.
American Psychological Association (APA)
Mizuno, Hideya& Fujikake, Nobuhiro& Wada, Keiji& Nagai, Yoshitaka. 2010. α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Journal of Analytical Methods in Chemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454950
Modern Language Association (MLA)
Mizuno, Hideya…[et al.]. α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Journal of Analytical Methods in Chemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-454950
American Medical Association (AMA)
Mizuno, Hideya& Fujikake, Nobuhiro& Wada, Keiji& Nagai, Yoshitaka. α-Synuclein Transgenic Drosophila As a Model of Parkinson's Disease and Related Synucleinopathies. Journal of Analytical Methods in Chemistry. 2010. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-454950
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-454950