Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats
Joint Authors
Hatanaka, Elaine
Silva Junior, Antonio José de Almeida
Curi, Rui
Pithon-Curi, Tania Cristina
Bortolon, José Ricardo
Newsholme, Philip
Murata, Gilson Masahiro
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In this study we evaluated the onset and resolution of inflammation in control and streptozotocin-induced diabetic rats subjected to a single session of intense exercise.
The following measurements were carried out prior to, immediately after, and 2 and 24 hours after exercise: plasma levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, CINC-2α/β, MIP-3α, and IL-6), immunoglobulins (IgA and IgM), acute phase proteins (CRP and C3), and creatine kinase (CK) activity.
We also examined the occurrence of macrophage death by measurements of macrophages necrosis (loss of membrane integrity) and DNA fragmentation.
An increase was observed in the concentration of IL-1β (3.3-fold) and TNF-α (2.0-fold) and in the proportion of necrotic macrophages (4.5-fold) in diabetic rats 24 hours after exercise, while the control group showed basal measurements.
Twenty-four hours after the exercise, serum CK activity was elevated in diabetic rats but not in control animals.
We concluded that lesion and inflammations resulting from intense exercise were greater and lasted longer in diabetic animals than in nondiabetic control rats.
American Psychological Association (APA)
Bortolon, José Ricardo& Silva Junior, Antonio José de Almeida& Murata, Gilson Masahiro& Newsholme, Philip& Curi, Rui& Pithon-Curi, Tania Cristina…[et al.]. 2012. Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455072
Modern Language Association (MLA)
Bortolon, José Ricardo…[et al.]. Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-455072
American Medical Association (AMA)
Bortolon, José Ricardo& Silva Junior, Antonio José de Almeida& Murata, Gilson Masahiro& Newsholme, Philip& Curi, Rui& Pithon-Curi, Tania Cristina…[et al.]. Persistence of Inflammatory Response to Intense Exercise in Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455072
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455072