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The “Natural” History of Medically Treated Temporal Lobe Epilepsy : What Can an Evidence-Based Approach Tell Us?
Joint Authors
Pohlmann-Eden, Bernhard
Josephson, Colin Bruce
Source
Epilepsy Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We systematically reviewed the literature to describe the “natural” history of medically treated temporal lobe epilepsy (TLE).
No population-based studies recruiting incident cases of TLE irrespective of age exist.
Prospective, population-based studies were limited to those recruiting only childhood-onset TLE or those reporting TLE as a subgroup of cohorts of focal epilepsies.
Few studies have been performed in the “MRI era” limiting information on natural history secondary to specific pathologies.
Available data suggests that TLE is highly variable, with unpredictable transient remissions and low rates of seizure freedom (30 to 50%).
Etiology and failure of first and second drug seem to be the most important predictors for treatment prognosis.
The role of initial precipitating injuries remains speculative, as imaging information of related events is either missing or conflicting.
Prospective cohorts of new-onset TLE with long-term followup using advanced MRI techniques, timely EEG recordings, and assessments of psychiatric comorbidities are needed.
American Psychological Association (APA)
Josephson, Colin Bruce& Pohlmann-Eden, Bernhard. 2012. The “Natural” History of Medically Treated Temporal Lobe Epilepsy : What Can an Evidence-Based Approach Tell Us?. Epilepsy Research and Treatment،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455319
Modern Language Association (MLA)
Josephson, Colin Bruce& Pohlmann-Eden, Bernhard. The “Natural” History of Medically Treated Temporal Lobe Epilepsy : What Can an Evidence-Based Approach Tell Us?. Epilepsy Research and Treatment No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-455319
American Medical Association (AMA)
Josephson, Colin Bruce& Pohlmann-Eden, Bernhard. The “Natural” History of Medically Treated Temporal Lobe Epilepsy : What Can an Evidence-Based Approach Tell Us?. Epilepsy Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-455319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455319