Implications of Heterogeneity in Multiple Myeloma
Joint Authors
Chng, Wee-Joo
Tung, Moon Ley
de Mel, Sanjay
Lim, Su Hong
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Multiple myeloma is the second most common hematologic malignancy in the world.
Despite improvement in outcome, the disease is still incurable for most patients.
However, not all myeloma are the same.
With the same treatment, some patients can have very long survival whereas others can have very short survival.
This suggests that there is underlying heterogeneity in myeloma.
Studies over the years have revealed multiple layers of heterogeneity.
First, clinical parameters such as age and tumor burden could significantly affect outcome.
At the genetic level, there are also significant heterogeneity ranging for chromosome numbers, genetic translocations, and genetic mutations.
At the clonal level, there appears to be significant clonal heterogeneity with multiple clones coexisting in the same patient.
At the cell differentiation level, there appears to be a hierarchy of clonally related cells that have different clonogenic potential and sensitivity to therapies.
These levels of complexities present challenges in terms of treatment and prognostication as well as monitoring of treatment.
However, if we can clearly delineate and dissect this heterogeneity, we may also be presented with unique opportunities for precision and personalized treatment of myeloma.
Some proof of concepts of such approaches has been demonstrated.
American Psychological Association (APA)
de Mel, Sanjay& Lim, Su Hong& Tung, Moon Ley& Chng, Wee-Joo. 2014. Implications of Heterogeneity in Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455903
Modern Language Association (MLA)
de Mel, Sanjay…[et al.]. Implications of Heterogeneity in Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-455903
American Medical Association (AMA)
de Mel, Sanjay& Lim, Su Hong& Tung, Moon Ley& Chng, Wee-Joo. Implications of Heterogeneity in Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-455903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-455903