Association between ε234, Promoter Polymorphism (−491AT, −427TC, and −219TG) at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China
Joint Authors
Gao, Xiaocai
Zhang, Fuchang
Li, Jun
Xing, Qinghe
Qian, Xueqing
Wang, Yunliang
Guo, Tingwei
He, Lin
Gao, Jianjun
Wang, Yan
Qin, Wei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Several common single-nucleotide polymorphisms (SNPs) at apolipoprotein E (ApoE) have been linked with late onset sporadic Alzheimer’s disease and declining normative cognitive ability in elder people, but we are unclear about their relationship with cognition in children.
Results.
We studied -491A/T, -427T/C, and -219G/T promoter polymorphisms and ε2/ε3/ε4 at ApoE among children with mental retardation (MR, n=130), borderline MR (n=124), and controls (n=334) from an iodine deficiency area in China.
The allelic and genotypic distribution of individual locus did not significantly differ among three groups with Mantel-Haenszel χ2 test (P>0.05).
However, frequencies of haplotype of -491A/-427T/-219T/ε4 were distributed as MR > borderline MR > controls (P uncorrected = 0.004), indicating that the presence of this haplotype may increase the risk of disease.
Conclusions.
In this large population-based study in children, we did not find any significant association between single locus of the four common ApoE polymorphisms (-491A/T, -427T/C, -219T/G, and ε2/3/4) and MR or borderline MR.
However, we found that the presence of ATTε4 haplotype was associated with an increased risk of MR and borderline MR.
Our present work may help enlarge our knowledge of the cognitive role of ApoE across the lifespan and the mechanisms of human cognition.
American Psychological Association (APA)
Li, Jun& Zhang, Fuchang& Wang, Yunliang& Wang, Yan& Qin, Wei& Xing, Qinghe…[et al.]. 2014. Association between ε234, Promoter Polymorphism (−491AT, −427TC, and −219TG) at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456177
Modern Language Association (MLA)
Li, Jun…[et al.]. Association between ε234, Promoter Polymorphism (−491AT, −427TC, and −219TG) at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-456177
American Medical Association (AMA)
Li, Jun& Zhang, Fuchang& Wang, Yunliang& Wang, Yan& Qin, Wei& Xing, Qinghe…[et al.]. Association between ε234, Promoter Polymorphism (−491AT, −427TC, and −219TG) at the Apolipoprotein E Gene, and Mental Retardation in Children from an Iodine Deficiency Area, China. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-456177
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456177