Encapsulation of Diclofenac Molecules into Poly(ε-Caprolactone) Electrospun Fibers for Delivery Protection
Joint Authors
Russo, Giuseppina
Vittoria, Vittoria
Tammaro, Loredana
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-12-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Mg-Al Hydrotalcite-like clay (LDH) intercalated with diclofenac anions (HTlc-DIC) was introduced into poly(ε-caprolactone) (PCL) in different concentrations by the electrospinning technique, and mats of nonwoven fibers were obtained and compared to the pristine pure electrospun PCL.
The fibers, characterized by X-ray diffraction, thermogravimetric analysis, and differential scanning calorimetry, show an exfoliated clay structure up to 3 wt%, a good thermal stability of the diclofenac molecules and a crystallinity of PCL comparable to the pure polymer.
The scanning electron microscopy revealed electrospun PCL and PCL composite fibers diameters ranging between 500 nm to 3.0 μm and a generally uniform thickness along the fibers.
As the results suggested the in vitro drug release from the composite fibers is remarkably slower than the release from the corresponding control spun solutions of PCL and diclofenac sodium salt.
Thus, HTlc-DIC/PCL fibrous membranes can be used as an antinflammatory scaffold for tissue engineering.
American Psychological Association (APA)
Tammaro, Loredana& Russo, Giuseppina& Vittoria, Vittoria. 2009. Encapsulation of Diclofenac Molecules into Poly(ε-Caprolactone) Electrospun Fibers for Delivery Protection. Journal of Nanomaterials،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-456314
Modern Language Association (MLA)
Tammaro, Loredana…[et al.]. Encapsulation of Diclofenac Molecules into Poly(ε-Caprolactone) Electrospun Fibers for Delivery Protection. Journal of Nanomaterials No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-456314
American Medical Association (AMA)
Tammaro, Loredana& Russo, Giuseppina& Vittoria, Vittoria. Encapsulation of Diclofenac Molecules into Poly(ε-Caprolactone) Electrospun Fibers for Delivery Protection. Journal of Nanomaterials. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-456314
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456314