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Endoplasmic Reticulum Stress and Parkinson’s Disease : The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease
Joint Authors
Kaneko, Masayuki
Okuma, Yasunobu
Omura, Tomohiro
Matsubara, Kazuo
Nomura, Yasuyuki
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Endoplasmic reticulum (ER) stress has been known to be involved in the pathogenesis of various diseases, particularly neurodegenerative disorders such as Parkinson’s disease (PD).
We previously identified the human ubiquitin ligase HRD1 that is associated with protection against ER stress and its associated apoptosis.
HRD1 promotes the ubiquitination and degradation of Parkin-associated endothelin receptor-like receptor (Pael-R), an ER stress inducer and causative factor of familial PD, thereby preventing Pael-R-induced neuronal cell death.
Moreover, upregulation of HRD1 by the antiepileptic drug zonisamide suppresses 6-hydroxydopamine-induced neuronal cell death.
We review recent progress in the studies on the mechanism of ER stress-induced neuronal death related to PD, particularly focusing on the involvement of HRD1 in the prevention of neuronal death as well as a potential therapeutic approach for PD based on the upregulation of HRD1.
American Psychological Association (APA)
Omura, Tomohiro& Kaneko, Masayuki& Okuma, Yasunobu& Matsubara, Kazuo& Nomura, Yasuyuki. 2013. Endoplasmic Reticulum Stress and Parkinson’s Disease : The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456501
Modern Language Association (MLA)
Omura, Tomohiro…[et al.]. Endoplasmic Reticulum Stress and Parkinson’s Disease : The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-456501
American Medical Association (AMA)
Omura, Tomohiro& Kaneko, Masayuki& Okuma, Yasunobu& Matsubara, Kazuo& Nomura, Yasuyuki. Endoplasmic Reticulum Stress and Parkinson’s Disease : The Role of HRD1 in Averting Apoptosis in Neurodegenerative Disease. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-456501
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456501