A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke
Joint Authors
Santalucia, Paola
Zecca, Bruno
Bolla, Giovanbattista
Torgano, Giuseppe
Maino, Alberto
Consonni, Dario
Mandelli, Clara
Casiraghi, Chiara
Source
Emergency Medicine International
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background and Scope.
Early etiologic diagnosis of ischemic stroke subtype guides acute management and treatment.
We aim to evaluate if plasma biomarkers can predict stroke subtypes in the early phase from stroke onset.
Methods.
Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP), D-dimer, C-reactive protein, serum albumin, and globulin levels have been investigated in 114 consecutive patients presenting at the emergency room within 6 hours of the ischemic stroke onset.
Plasma levels of biomarkers have been correlated with stroke aetiology (based on TOAST criteria) by multivariable logistic regression analysis, adjusted for several covariates.
Results.
Of the 114 patients, 34 (30%) had cardioembolic stroke, 27 (23%) atherothrombotic stroke, 19 (17%) lacunar stroke, and 34 (30%) stroke of undetermined origin.
Patients with cardioembolic stroke had significantly higher levels of NT-proBNP and lower globulin/albumin (G/A) ratio compared with the other subgroups.
At multiple logistic regression NT-proBNP>200 pg/mL, G/A ratio>0.70, and NIHSS score were independent predictors of cardioembolic stroke with high accuracy of the model, either including (AUC, 0.91) or excluding (AUC, 0.84) atrial fibrillation.
Conclusions.
A prediction model that includes NT-proBNP, G/A ratio, and NIHSS score can be useful for the early etiologic diagnosis of ischemic stroke.
American Psychological Association (APA)
Zecca, Bruno& Mandelli, Clara& Maino, Alberto& Casiraghi, Chiara& Bolla, Giovanbattista& Consonni, Dario…[et al.]. 2014. A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke. Emergency Medicine International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-456697
Modern Language Association (MLA)
Zecca, Bruno…[et al.]. A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke. Emergency Medicine International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-456697
American Medical Association (AMA)
Zecca, Bruno& Mandelli, Clara& Maino, Alberto& Casiraghi, Chiara& Bolla, Giovanbattista& Consonni, Dario…[et al.]. A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke. Emergency Medicine International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-456697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456697