PKM2, a Central Point of Regulation in Cancer Metabolism
Joint Authors
De Melo, Jason
Tang, Damu
Wong, Nicholas
Source
International Journal of Cell Biology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aerobic glycolysis is the dominant metabolic pathway utilized by cancer cells, owing to its ability to divert glucose metabolites from ATP production towards the synthesis of cellular building blocks (nucleotides, amino acids, and lipids) to meet the demands of proliferation.
The M2 isoform of pyruvate kinase (PKM2) catalyzes the final and also a rate-limiting reaction in the glycolytic pathway.
In the PK family, PKM2 is subjected to a complex regulation by both oncogenes and tumour suppressors, which allows for a fine-tone regulation of PKM2 activity.
The less active form of PKM2 drives glucose through the route of aerobic glycolysis, while active PKM2 directs glucose towards oxidative metabolism.
Additionally, PKM2 possesses protein tyrosine kinase activity and plays a role in modulating gene expression and thereby contributing to tumorigenesis.
We will discuss our current understanding of PKM2's regulation and its many contributions to tumorigenesis.
American Psychological Association (APA)
Wong, Nicholas& De Melo, Jason& Tang, Damu. 2013. PKM2, a Central Point of Regulation in Cancer Metabolism. International Journal of Cell Biology،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-456713
Modern Language Association (MLA)
Wong, Nicholas…[et al.]. PKM2, a Central Point of Regulation in Cancer Metabolism. International Journal of Cell Biology No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-456713
American Medical Association (AMA)
Wong, Nicholas& De Melo, Jason& Tang, Damu. PKM2, a Central Point of Regulation in Cancer Metabolism. International Journal of Cell Biology. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-456713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456713