Antioxidants for Preventing Preeclampsia : A Systematic Review
Joint Authors
Motta, Lucilia Casulari Domingues
Galvao, Tais Freire
Salles, Adriana Magalhaes Ribeiro
Pereira, Mauricio Gomes
Silva, Marcus Tolentino
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Objective.
To investigate the efficacy of antioxidants for preventing preeclampsia and other maternal and fetal complications among pregnant women with low, moderate, or high risk of preeclampsia.
Methods.
We searched MEDLINE, Embase, CENTRAL, mRCT, and other databases, with no language or publication restrictions.
Two independent reviewers selected randomized controlled trials that evaluated the use of antioxidants versus placebo and extracted the relevant data.
Relative risks (RRs) and 95% confidence intervals (95% CIs) were calculated.
The data were compiled through the random effects model.
Main Results.
Fifteen studies were included (21,012 women and 21,647 fetuses).
No statistically significant difference was found between women who received antioxidant treatment and women who received placebo for preeclampsia (RR =0.92; 95% CI: 0.82–1.04), severe preeclampsia (RR =1.03; 95% CI: 0.87–1.22), preterm birth (RR =1.03; 95% CI: 0.94–1.14), and small for gestational age <10th centile (RR =0.92; 95% CI: 0.80–1.05).
Side effects were numerically more frequent in the antioxidants group compared to placebo, but without significant statistical difference (RR =1.24; 95% CI: 0.85–1.80).
Conclusions.
The available evidence reviewed does not support the use of antioxidants during pregnancy for the prevention of preeclampsia and other outcomes.
American Psychological Association (APA)
Salles, Adriana Magalhaes Ribeiro& Galvao, Tais Freire& Silva, Marcus Tolentino& Motta, Lucilia Casulari Domingues& Pereira, Mauricio Gomes. 2012. Antioxidants for Preventing Preeclampsia : A Systematic Review. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456796
Modern Language Association (MLA)
Salles, Adriana Magalhaes Ribeiro…[et al.]. Antioxidants for Preventing Preeclampsia : A Systematic Review. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-456796
American Medical Association (AMA)
Salles, Adriana Magalhaes Ribeiro& Galvao, Tais Freire& Silva, Marcus Tolentino& Motta, Lucilia Casulari Domingues& Pereira, Mauricio Gomes. Antioxidants for Preventing Preeclampsia : A Systematic Review. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-456796
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456796