PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease
Joint Authors
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-07
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The circadian rhythm, controlled by a complex network of cellular transcription factors, orchestrates behavior and physiology in the vast majority of animals.
The circadian system is comprised of a master clock located in central nervous system with 24-hour rotation and periphery clocks to ensure optimal timing of physiology in peripheral tissues.
Circadian expression of peroxisome proliferator-activated receptors (PPARs), members of the nuclear receptor superfamily and key mediators of energy homeostasis and metabolism, is regulated by clock genes.
PPARs serve as sensors of nutrient and energy/metabolism status to temporally entrain peripheral clock.
Metabolism and circadian clocks are tightly intertwined: clock genes drive metabolism, and various metabolic parameters affect clock genes, producing a reciprocal feedback relationship.
Due to PPARs' robust relationship with energy status and metabolism, the aberration of PPARs in the biological clock system leads to abnormal expression of genes in metabolic pathways, thus, contributing to etiology of metabolic syndrome.
Studying PPARs' functions under the context of the mammalian circadian system could advance our understanding of how energy and metabolic status are maintained in the body, which may ultimately lead to rhythmic medical treatment against metabolic syndrome.
American Psychological Association (APA)
Charoensuksai, Purin& Xu, Wei. 2010. PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease. PPAR Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-456811
Modern Language Association (MLA)
Charoensuksai, Purin& Xu, Wei. PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease. PPAR Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-456811
American Medical Association (AMA)
Charoensuksai, Purin& Xu, Wei. PPARs in Rhythmic Metabolic Regulation and Implications in Health and Disease. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-456811
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456811