The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status
Joint Authors
Janicijevic-Hudomal, Snezana
Stolic, Radojica V.
Miric, Dijana
Kisic, Bojana
Miric, Bratislav
Mitic, Radoslav
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The role of xanthine oxidase (XOD) in patients undergoing chronic hemodialysis treatment (HD) is poorly understood.
Geriatric nutritional risk index (GNRI) ≤ 90 could be linked with malnutrition-inflammation complex syndrome.
This study measured XOD, myeloperoxidase (MPO), superoxide dismutase (SOD), lipid hydroperoxides, total free thiol groups, and advanced oxidation protein products (AOPP) in 50 HD patients before commencing (pre-HD) and immediately after completion of HD session (post-HD) and in 22 healthy controls.
Pre-HD serum hydroperoxides, AOPP, XOD, and SOD were higher and total thiol groups were lower in patients than in controls (P<0.05, resp.).
Compared to baseline values, serum MPO activity was increased irrespective of GNRI status.
Serum XOD activity was increasing during HD treatment in the group with GNRI ≤ 90 (P=0.030) whilst decreasing in the group with GNRI > 90 (P=0.002).
In a multiple regression analysis, post-HD serum XOD activity was independently associated with GNRI ≤ 90 (β ± SE: 0.398 ± 0.151; P=0.012) and HD vintage (β ± SE: −0.349 ± 0.139; P=0.016).
These results indicate that an upregulated XOD may be implicated in HD-induced oxidative injury contributing to accelerated protein damage in patients with GNRI ≤ 90.
American Psychological Association (APA)
Miric, Dijana& Kisic, Bojana& Stolic, Radojica V.& Miric, Bratislav& Mitic, Radoslav& Janicijevic-Hudomal, Snezana. 2013. The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456879
Modern Language Association (MLA)
Miric, Dijana…[et al.]. The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-456879
American Medical Association (AMA)
Miric, Dijana& Kisic, Bojana& Stolic, Radojica V.& Miric, Bratislav& Mitic, Radoslav& Janicijevic-Hudomal, Snezana. The Role of Xanthine Oxidase in Hemodialysis-Induced Oxidative Injury : Relationship with Nutritional Status. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-456879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-456879