Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis
Joint Authors
Dolff, Sebastian
Witzke, Oliver
Kribben, Andreas
Hoerning, André
Wilde, Benjamin
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background/Aim.
ANCA-associated vasculitis (AAV) is a small-vessel vasculitis of autoimmune origin.
In addition to autoantibodies, T cells have a pivotal pathophysiological role in this disease.
T-cell homeostasis and immune tolerance critically depend on IL-2 and its receptor expressed by T cells.
In this study, we investigated the IL-2 receptor (IL-2r) expression on CD4+ T cells in AAV.
Methods.
Thirty patients with AAV and 15 age-matched healthy controls (HC) were enrolled.
T cells from peripheral blood were analysed by flow cytometry for expression of the IL-2r α- and β-chain.
Results.
The IL-2r α-chain was overexpressed in AAV as compared to HC (36±16% versus 20±9%, P<0.005).
The IL-2r-β-chain expression was significantly reduced on CD25+ CD4+ T-cells and CD4+CD25+FoxP3pos regulatory T-cells (Tregs; AAV versus HC: 48±14% versus 62±9%, P=0.002 and 38±18% versus 68±5%, P=0.002).
Low β-chain expression in AAV was associated with relapsing disease and systemic vasculitis with renal involvement.
Conclusion.
The IL-2r expression pattern is abnormal in AAV.
To our knowledge, we are the first to show that the β-chain expression is drastically diminished on T cells in AAV and related to a less favorable disease course.
Given the indispensable function of the β-chain in IL-2 signaling of T cells, diminished expression may contribute to disturbed immune homeostasis in AAV.
American Psychological Association (APA)
Wilde, Benjamin& Hoerning, André& Kribben, Andreas& Witzke, Oliver& Dolff, Sebastian. 2014. Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457344
Modern Language Association (MLA)
Wilde, Benjamin…[et al.]. Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-457344
American Medical Association (AMA)
Wilde, Benjamin& Hoerning, André& Kribben, Andreas& Witzke, Oliver& Dolff, Sebastian. Abnormal Expression Pattern of the IL-2 Receptor β-Chain on CD4+ T Cells in ANCA-Associated Vasculitis. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-457344
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457344