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Peroxisome Proliferator-Activated Receptor-γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer
Joint Authors
Matsuyama, Masahide
Yoshimura, Rikio
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor-γ (PPAR)-γ is a ligand-activated transcriptional factor belonging to steroid receptor superfamily.
PPAR-γ plays a role in both adipocyte differentiation and tumorigenesis.
Up to date, PPAR-γ is expressed in various cancer tissues, and PPAR-γ ligand induces growth arrest of these cancer cells.
In this study, we examined the expression of PPAR-γ in prostate cancer (PC) and testicular cancer (TC) by RT-PCR and immunohistochemistry, and we also examined the effect of PPAR-γ ligand in these cells by MTT assay, hoechest staining, and flow cytometry.
PPAR-γ expression was significantly more extensive and intense in malignant tissues than in normal tissues.
PPAR-γ ligand induced the reduction of malignant cell viability through apoptosis.
These results demonstrated that the generated PPAR-γ in PC and TC cells might play an important role in the tumorigenesis.
PPAR-γ may become a new target in the treatment of PC and TC.
American Psychological Association (APA)
Matsuyama, Masahide& Yoshimura, Rikio. 2008. Peroxisome Proliferator-Activated Receptor-γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer. PPAR Research،Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-457345
Modern Language Association (MLA)
Matsuyama, Masahide& Yoshimura, Rikio. Peroxisome Proliferator-Activated Receptor-γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer. PPAR Research No. 2008 (2008), pp.1-12.
https://search.emarefa.net/detail/BIM-457345
American Medical Association (AMA)
Matsuyama, Masahide& Yoshimura, Rikio. Peroxisome Proliferator-Activated Receptor-γ Is a Potent Target for Prevention and Treatment in Human Prostate and Testicular Cancer. PPAR Research. 2008. Vol. 2008, no. 2008, pp.1-12.
https://search.emarefa.net/detail/BIM-457345
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457345