Effect of αB-Crystallin on Protein Aggregation in Drosophila
Joint Authors
Shimaji, Kouhei
Yamaguchi, Masamitsu
Tue, Nguyen Trong
Tanaka, Naoki
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Disorganisation and aggregation of proteins containing expanded polyglutamine (polyQ) repeats, or ectopic expression of α-synuclein, underlie neurodegenerative diseases including Alzheimer’s, Parkinson, Huntington, Creutzfeldt diseases.
Small heat-shock proteins, such as αB-crystallin, act as chaperones to prevent protein aggregation and play a key role in the prevention of such protein disorganisation diseases.
In this study, we have explored the potential for chaperone activity of αB-crystallin to suppress the formation of protein aggregates.
We tested the ability of αB-crystallin to suppress the aggregation of a polyQ protein and α-synuclein in Drosophila.
We found that αB-crystallin suppresses both the compound eye degeneration induced by polyQ and the α-synuclein-induced rough eye phenotype.
Furthermore, by using histochemical staining we have determined that αB-crystallin inhibits the aggregation of polyQ in vivo.
These data provide a clue for the development of therapeutics for neurodegenerative diseases.
American Psychological Association (APA)
Tue, Nguyen Trong& Shimaji, Kouhei& Tanaka, Naoki& Yamaguchi, Masamitsu. 2012. Effect of αB-Crystallin on Protein Aggregation in Drosophila. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457560
Modern Language Association (MLA)
Tue, Nguyen Trong…[et al.]. Effect of αB-Crystallin on Protein Aggregation in Drosophila. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-457560
American Medical Association (AMA)
Tue, Nguyen Trong& Shimaji, Kouhei& Tanaka, Naoki& Yamaguchi, Masamitsu. Effect of αB-Crystallin on Protein Aggregation in Drosophila. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-457560
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-457560